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How to Design NMR Bio-Probes

With unprecedented precision, chemists at IRAMIS developed a model describing an NMR probe containing an atomic probe (polarized xenon) and a molecule that selectively reacts with a target of biological interest. This model was validated by experiments conducted in collaboration with researchers from iBiTec-S (Life Sciences Division). The probes described in this study combine the spectacular NMR detection sensitivity of polarized xenon with a great selectivity towards the targeted biochemical environment permitted by NMR.

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